3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34; UniProt P00347; also known as HMG-CoA reductase) is encoded by the HMGCR gene (Gene ID

View application images and datasheets for 163 anti HMGCR Antibody antibodies from 20 leading antibody suppliers, plus reviews and the top related antibodies

HMGCR Ab Necrotizing autoimmune myopathy (NAM) HMGCR Antibodies Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal Necrotizing autoimmune myopathy (NAM) is a serious but rare muscle disease strongly associated with autoantibodies to either signal recognition protein (SRP) or 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR). HMGCR Abs (3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase) are associated with necrotizing myopathy that is commonly related to statin exposure. Recently, auto-antibodies (AAbs) to the enzyme, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) was shown to be a MSA that was strongly associated with immune mediated necrotising myopathy (Arthritis Rheum. 2010 Sep;62(9):2757-66. doi: 10.1002/art.27572). HMGCR AAb positive patients present with progressive, irritable myopathy of the proximal HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase) is also named as HMG-CoA reductase and belongs to the HMG-CoA reductase family. HMGCR Antibody (PA5-37367) in WB Western blot analysis of HMGCR in extracts of various cells using HMGCR polyclonal antibody (Product # PA5-37367).

Hmgcr antibody

Anti‐HMGCR antibodies are considered relatively specific for necrotizing myositis and are usually associated with statin exposure 12, 13. As a single case report, the presented clinical and laboratory findings can only be considered hypothesis generating. Statins and myositis: the role of anti-HMGCR antibodies Muscle toxicity is a recognized adverse effect of statin use. Recently, a new myositis syndrome was described in association with antibodies directed against the pharmacologic target of statins, anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR antibody).

Jun 4, 2015 Patients with HMGCR antibody–associated myopathies present with weakness and muscle discomfort and often have damage to both perimysial

If you continue, we'll assume that you are happy to receive all cookies. HMGCR antibodies. HMGCR Antibody, Biotin conjugated ( ELISA ) ( CSB-PA010565LD01HU ) HMGCR Antibody, HRP conjugated ( ELISA ) ( CSB-PA010565LB01HU ) HMGCR Antibody, FITC conjugated ( ELISA ) ( CSB-PA010565LC01HU ) HMGCR Antibody ( ELISA,IHC ) ( CSB-PA031676 ) HMGCR Antibody ( ELISA,IHC ) ( CSB-PA929004 ) More>> HMGCR Proteins Select HMGCR antibodies from monoclonal antibodies listed below.

LIA f, u f, u SRP-antikroppar HMGCR-antikroppar SRPAb HMGCRAb Kä Anti-phospholipid antibodies may indicate phospholipid antibody syndrome.

This antibody reacts with Human, Mouse, Rat samples. Supplied as 100 µL purified antibody (1 mg/mL). HMGCR antibodies Indication Suspicion of immune-mediated necrotizing myopathy (IMNM). Anti-HMCGR is strongly associated with previous statin therapy.

浓度: 1mg/ml. 保存条件: Summaries for HMGCR gene (According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL) About This Sectio Product Name: HMGCR antibody: Catalog Number: orb228653: Species/Host: Rabbit: Reactivity: Human, Mouse, Rat: Conjugation: Unconjugated: Tested applications: IHC-P, WB Rabbit recombinant monoclonal HMGCR antibody [EPR1685(N)]. Validated in WB, IP and tested in Mouse, Rat, Human. Cited in 53 publication(s). 343 products Anti-HMGCR antibodies are offered by a number of suppliers. This target gene encodes the protein '3-hydroxy-3-methylglutaryl-CoA reductase' in HPA008338 Sigma-Aldrich.
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Grik2, also known as glutamate receptor 6, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. HMGCR Autoantibodies. Also known as: HMG; Statin associated myopathy; necrotising myopathy. The clinical management of inflammatory myopathies can be guided according to the demonstation of Myositis specific autoantibodies (MSA).
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HMGCR Antibody: Chronic Myopathy, Young onset. VvG stain: Myopathic features Muscle fibers Internal architecture: May have aggregates Size: Varied Regenerating muscle fibers: Scattered Endomysial connective tissue: Increased Severity of pathology: May vary among fascicles.

HMGCR Autoantibodies. Also known as: HMG; Statin associated myopathy; necrotising myopathy.